Jason Hlozek

 

 

 

 

Jason Hlozek

Jason obtained his B.Sc. in Chemistry and Computer Science from the University of Cape Town (UCT) in 2014, followed by a B.Sc. Honours in Computer Science in 2015.He then joined the Bioanalytical and Vaccine Research Group from 2016 to 2020, where he obtained his PhD in Chemistry under the supervision of Prof. Neil Ravenscroft (Chemistry) and co-supervision of Prof. Michelle Kuttel (Chemistry). His PhD work focused on the computational modelling of bacterial carbohydrate antigens to advance the understanding of vaccine cross-protection phenomena to promote the rational design of optimal multivalent vaccines. He has authored several publications on the conformational analysis of polysaccharides corresponding to strains of Neisseria meningitidis and Shigella flexneri, pathogenic bacteria that predominantly burden low-income settings. Jason is passionate about interdisciplinary research and work that will make a positive and tangible impact on society. In May 2021, he joined the Kelly Chibale research group and H3D as a postdoctoral research fellow, pursuing research in the field of artificial intelligence (AI) and Machine Learning (ML) with the application of accelerating drug discovery and development.

 

Koketso Mogwera

 

 

 

 

Koketso Mogwera

Koketso is a Postdoctoral research fellow working on target-based drug discovery approaches. She obtained an MSc. in Biochemistry from the University of Johannesburg in 2015. Her research dissertation was on the spectroscopic analysis of secondary structures of human linker histone variants. She went on to obtain a PhD in Biochemistry from Stellenbosch University. Her PhD thesis was on membrane transport and permeability studies of Coenzyme A, its intermediates and antimetabolites. Part of her PhD focused on the mechanistic investigation of bacterial kinases to understand the molecular determinants of substrate selectivity in these enzymes. She is now applying the approaches and techniques learnt from that study in her current research project which entails the application of mechanistic enzymology and structural biology principles in targeting Plasmodium falciparum kinases for the development of novel antimalarial agents. Koketso has a friendly demeanor and believes in a systematic approach to a research problem. Her time outside the research lab is spent on leisure reading, road running, hiking and she is also a performing arts enthusiast.